Histone H2AX (H2AX)

About Histone H2AX

Histone H2AX (H2AX) is a protein from Homo sapiens identified by UniProt accession P16104, 143 residues long. MolForge cross-references it against 0 known binders and 388 disease associations.

Target properties

Protein name	Histone H2AX
UniProt accession	P16104
Gene	H2AX
Organism	Homo sapiens
Length	143 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (388)

Diseases linked to this target (Open Targets).

cancer · score 0.39
melanoma · score 0.38
breast carcinoma · score 0.37
hepatocellular carcinoma · score 0.11
neoplasm · score 0.11
breast cancer · score 0.09
infection · score 0.09
infect · score 0.09
head and neck squamous cell carcinoma · score 0.07
gastrointestinal stromal tumor · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P16104-F1	alphafold	PREDICTED	86.32	—

Amino-acid sequence (143 residues)

MSGRGKTGGK ARAKAKSRSS RAGLQFPVGR VHRLLRKGHY AERVGAGAPV YLAAVLEYLT AEILELAGNA ARDNKKTRII PRHLQLAIRN DEELNKLLGG VTIAQGGVLP NIQAVLLPKK TSATVGPKAP SGGKKATQAS QEY

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards