About Short-chain specific acyl-CoA dehydrogenase, mitochondrial
Short-chain specific acyl-CoA dehydrogenase, mitochondrial (ACADS) is a protein
from Homo sapiens identified by UniProt accession
P16219, 412 residues long.
MolForge cross-references it against 0 known binders and
151 disease associations.
Target properties
| Protein name | Short-chain specific acyl-CoA dehydrogenase, mitochondrial |
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| UniProt accession | P16219 |
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| Gene | ACADS |
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| Organism | Homo sapiens |
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| Length | 412 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (151)
Diseases linked to this target (Open Targets).
- short chain acyl-CoA dehydrogenase deficiency · score 0.84
- genetic disorder · score 0.47
- serum metabolite measurement · score 0.45
- urinary metabolite measurement · score 0.41
- mean corpuscular volume · score 0.36
- metabolite measurement · score 0.35
- total blood protein measurement · score 0.33
- protein measurement · score 0.33
- vital capacity · score 0.32
- acylcarnitine measurement · score 0.29
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P16219-F1 | alphafold | PREDICTED | 93.65 | — |
Amino-acid sequence (412 residues)
MAAALLARAS GPARRALCPR AWRQLHTIYQ SVELPETHQM LLQTCRDFAE KELFPIAAQV DKEHLFPAAQ VKKMGGLGLL AMDVPEELGG AGLDYLAYAI AMEEISRGCA STGVIMSVNN SLYLGPILKF GSKEQKQAWV TPFTSGDKIG CFALSEPGNG SDAGAASTTA RAEGDSWVLN GTKAWITNAW EASAAVVFAS TDRALQNKGI SAFLVPMPTP GLTLGKKEDK LGIRGSSTAN LIFEDCRIPK DSILGEPGMG FKIAMQTLDM GRIGIASQAL GIAQTALDCA VNYAENRMAF GAPLTKLQVI QFKLADMALA LESARLLTWR AAMLKDNKKP FIKEAAMAKL AASEAATAIS HQAIQILGGM GYVTEMPAER HYRDARITEI YEGTSEIQRL VIAGHLLRSY RS
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