About Platelet endothelial cell adhesion molecule
Platelet endothelial cell adhesion molecule (PECAM1) is a protein
from Homo sapiens identified by UniProt accession
P16284, 738 residues long.
MolForge cross-references it against 0 known binders and
953 disease associations.
Target properties
| Protein name | Platelet endothelial cell adhesion molecule |
|---|
| UniProt accession | P16284 |
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| Gene | PECAM1 |
|---|
| Organism | Homo sapiens |
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| Length | 738 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (953)
Diseases linked to this target (Open Targets).
- multiple sclerosis · score 0.30
- Alzheimer disease · score 0.29
- Parkinson disease · score 0.29
- lysosomal storage disease · score 0.29
- neurodegenerative disease · score 0.29
- systolic blood pressure · score 0.28
- pulse pressure measurement · score 0.26
- coronary artery disease · score 0.26
- mean platelet volume · score 0.22
- myocardial infarction · score 0.17
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P16284-F1 | alphafold | PREDICTED | 80.43 | — |
Amino-acid sequence (738 residues)
MQPRWAQGAT MWLGVLLTLL LCSSLEGQEN SFTINSVDMK SLPDWTVQNG KNLTLQCFAD VSTTSHVKPQ HQMLFYKDDV LFYNISSMKS TESYFIPEVR IYDSGTYKCT VIVNNKEKTT AEYQVLVEGV PSPRVTLDKK EAIQGGIVRV NCSVPEEKAP IHFTIEKLEL NEKMVKLKRE KNSRDQNFVI LEFPVEEQDR VLSFRCQARI ISGIHMQTSE STKSELVTVT ESFSTPKFHI SPTGMIMEGA QLHIKCTIQV THLAQEFPEI IIQKDKAIVA HNRHGNKAVY SVMAMVEHSG NYTCKVESSR ISKVSSIVVN ITELFSKPEL ESSFTHLDQG ERLNLSCSIP GAPPANFTIQ KEDTIVSQTQ DFTKIASKSD SGTYICTAGI DKVVKKSNTV QIVVCEMLSQ PRISYDAQFE VIKGQTIEVR CESISGTLPI SYQLLKTSKV LENSTKNSND PAVFKDNPTE DVEYQCVADN CHSHAKMLSE VLRVKVIAPV DEVQISILSS KVVESGEDIV LQCAVNEGSG PITYKFYREK EGKPFYQMTS NATQAFWTKQ KASKEQEGEY YCTAFNRANH ASSVPRSKIL TVRVILAPWK KGLIAVVIIG VIIALLIIAA KCYFLRKAKA KQMPVEMSRP AVPLLNSNNE KMSDPNMEAN SHYGHNDDVR NHAMKPINDN KEPLNSDVQY TEVQVSSAES HKDLGKKDTE TVYSEVRKAV PDAVESRYSR TEGSLDGT
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