About Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform
Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform (PPP3CB) is a protein
from Homo sapiens identified by UniProt accession
P16298, 524 residues long.
MolForge cross-references it against 0 known binders and
168 disease associations.
Target properties
| Protein name | Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform |
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| UniProt accession | P16298 |
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| Gene | PPP3CB |
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| Organism | Homo sapiens |
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| Length | 524 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (168)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.41
- endometrial cancer · score 0.24
- Alzheimer disease · score 0.15
- Parkinson disease · score 0.15
- multiple sclerosis · score 0.15
- lysosomal storage disease · score 0.15
- lung adenocarcinoma · score 0.10
- Chronic mucocutaneous candidosis · score 0.10
- Okt4 epitope deficiency · score 0.08
- 22q11.2 deletion syndrome · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P16298-F1 | alphafold | PREDICTED | 85.09 | — |
Amino-acid sequence (524 residues)
MAAPEPARAA PPPPPPPPPP PGADRVVKAV PFPPTHRLTS EEVFDLDGIP RVDVLKNHLV KEGRVDEEIA LRIINEGAAI LRREKTMIEV EAPITVCGDI HGQFFDLMKL FEVGGSPANT RYLFLGDYVD RGYFSIECVL YLWVLKILYP STLFLLRGNH ECRHLTEYFT FKQECKIKYS ERVYEACMEA FDSLPLAALL NQQFLCVHGG LSPEIHTLDD IRRLDRFKEP PAFGPMCDLL WSDPSEDFGN EKSQEHFSHN TVRGCSYFYN YPAVCEFLQN NNLLSIIRAH EAQDAGYRMY RKSQTTGFPS LITIFSAPNY LDVYNNKAAV LKYENNVMNI RQFNCSPHPY WLPNFMDVFT WSLPFVGEKV TEMLVNVLSI CSDDELMTEG EDQFDGSAAA RKEIIRNKIR AIGKMARVFS VLREESESVL TLKGLTPTGM LPSGVLAGGR QTLQSATVEA IEAEKAIRGF SPPHRICSFE EAKGLDRINE RMPPRKDAVQ QDGFNSLNTA HATENHGTGN HTAQ
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