SH2/SH3 adapter protein NCK1 (NCK1)

About SH2/SH3 adapter protein NCK1

SH2/SH3 adapter protein NCK1 (NCK1) is a protein from Homo sapiens identified by UniProt accession P16333, 377 residues long. MolForge cross-references it against 0 known binders and 177 disease associations.

Target properties

Protein name	SH2/SH3 adapter protein NCK1
UniProt accession	P16333
Gene	NCK1
Organism	Homo sapiens
Length	377 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (177)

Diseases linked to this target (Open Targets).

platelet count · score 0.41
lymphocyte count · score 0.39
monocyte count · score 0.37
sex hormone-binding globulin measurement · score 0.37
bilirubin measurement · score 0.36
leukocyte count · score 0.36
myeloid white cell count · score 0.32
platelet crit · score 0.31
Red cell distribution width · score 0.30
body height · score 0.29

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P16333-F1	alphafold	PREDICTED	70.77	—

Amino-acid sequence (377 residues)

MAEEVVVVAK FDYVAQQEQE LDIKKNERLW LLDDSKSWWR VRNSMNKTGF VPSNYVERKN SARKASIVKN LKDTLGIGKV KRKPSVPDSA SPADDSFVDP GERLYDLNMP AYVKFNYMAE REDELSLIKG TKVIVMEKCS DGWWRGSYNG QVGWFPSNYV TEEGDSPLGD HVGSLSEKLA AVVNNLNTGQ VLHVVQALYP FSSSNDEELN FEKGDVMDVI EKPENDPEWW KCRKINGMVG LVPKNYVTVM QNNPLTSGLE PSPPQCDYIR PSLTGKFAGN PWYYGKVTRH QAEMALNERG HEGDFLIRDS ESSPNDFSVS LKAQGKNKHF KVQLKETVYC IGQRKFSTME ELVEHYKKAP IFTSEQGEKL YLVKHLS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards