About Potassium voltage-gated channel subfamily A member 2
Potassium voltage-gated channel subfamily A member 2 (KCNA2) is a protein
from Homo sapiens identified by UniProt accession
P16389, 499 residues long.
MolForge cross-references it against 0 known binders and
314 disease associations.
Target properties
| Protein name | Potassium voltage-gated channel subfamily A member 2 |
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| UniProt accession | P16389 |
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| Gene | KCNA2 |
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| Organism | Homo sapiens |
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| Length | 499 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (314)
Diseases linked to this target (Open Targets).
- undetermined early-onset epileptic encephalopathy · score 0.75
- developmental and epileptic encephalopathy · score 0.66
- multiple sclerosis · score 0.59
- Myasthenia gravis · score 0.57
- genetic disorder · score 0.51
- Seizure · score 0.50
- small cell carcinoma · score 0.46
- Muscle weakness · score 0.46
- secondary progressive multiple sclerosis · score 0.43
- Neurodevelopmental disorder · score 0.41
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P16389-F1 | alphafold | PREDICTED | 77.39 | — |
Amino-acid sequence (499 residues)
MTVATGDPAD EAAALPGHPQ DTYDPEADHE CCERVVINIS GLRFETQLKT LAQFPETLLG DPKKRMRYFD PLRNEYFFDR NRPSFDAILY YYQSGGRLRR PVNVPLDIFS EEIRFYELGE EAMEMFREDE GYIKEEERPL PENEFQRQVW LLFEYPESSG PARIIAIVSV MVILISIVSF CLETLPIFRD ENEDMHGSGV TFHTYSNSTI GYQQSTSFTD PFFIVETLCI IWFSFEFLVR FFACPSKAGF FTNIMNIIDI VAIIPYFITL GTELAEKPED AQQGQQAMSL AILRVIRLVR VFRIFKLSRH SKGLQILGQT LKASMRELGL LIFFLFIGVI LFSSAVYFAE ADERESQFPS IPDAFWWAVV SMTTVGYGDM VPTTIGGKIV GSLCAIAGVL TIALPVPVIV SNFNYFYHRE TEGEEQAQYL QVTSCPKIPS SPDLKKSRSA STISKSDYME IQEGVNNSNE DFREENLKTA NCTLANTNYV NITKMLTDV
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