About Histone H1.5
Histone H1.5 (H1-5) is a protein
from Homo sapiens identified by UniProt accession
P16401, 226 residues long.
MolForge cross-references it against 0 known binders and
127 disease associations.
Target properties
| Protein name | Histone H1.5 |
|---|
| UniProt accession | P16401 |
|---|
| Gene | H1-5 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 226 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (127)
Diseases linked to this target (Open Targets).
- mean corpuscular volume · score 0.24
- Red cell distribution width · score 0.24
- hemoglobin measurement · score 0.18
- mean corpuscular hemoglobin concentration · score 0.17
- reticulocyte count · score 0.16
- mean platelet volume · score 0.16
- drug use measurement · score 0.13
- reticulocyte measurement · score 0.12
- breast carcinoma · score 0.10
- systemic lupus erythematosus · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P16401-F1 | alphafold | PREDICTED | 63.93 | — |
Amino-acid sequence (226 residues)
MSETAPAETA TPAPVEKSPA KKKATKKAAG AGAAKRKATG PPVSELITKA VAASKERNGL SLAALKKALA AGGYDVEKNN SRIKLGLKSL VSKGTLVQTK GTGASGSFKL NKKAASGEAK PKAKKAGAAK AKKPAGATPK KAKKAAGAKK AVKKTPKKAK KPAAAGVKKV AKSPKKAKAA AKPKKATKSP AKPKAVKPKA AKPKAAKPKA AKPKAAKAKK AAAKKK
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