About Histone H1.2
Histone H1.2 (H1-2) is a protein
from Homo sapiens identified by UniProt accession
P16403, 213 residues long.
MolForge cross-references it against 0 known binders and
115 disease associations.
Target properties
| Protein name | Histone H1.2 |
|---|
| UniProt accession | P16403 |
|---|
| Gene | H1-2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 213 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (115)
Diseases linked to this target (Open Targets).
- mean corpuscular hemoglobin · score 0.23
- HbA1c measurement · score 0.11
- mean corpuscular volume · score 0.11
- cardiovascular disease · score 0.08
- reticulocyte count · score 0.08
- allergic rhinitis · score 0.08
- Eczematoid dermatitis · score 0.08
- aspartate aminotransferase measurement · score 0.08
- seasonal allergic rhinitis · score 0.07
- Red cell distribution width · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P16403-F1 | alphafold | PREDICTED | 64.90 | — |
Amino-acid sequence (213 residues)
MSETAPAAPA AAPPAEKAPV KKKAAKKAGG TPRKASGPPV SELITKAVAA SKERSGVSLA ALKKALAAAG YDVEKNNSRI KLGLKSLVSK GTLVQTKGTG ASGSFKLNKK AASGEAKPKV KKAGGTKPKK PVGAAKKPKK AAGGATPKKS AKKTPKKAKK PAAATVTKKV AKSPKKAKVA KPKKAAKSAA KAVKPKAAKP KVVKPKKAAP KKK
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