Cytotoxic T-lymphocyte protein 4 (CTLA4)

About Cytotoxic T-lymphocyte protein 4

Cytotoxic T-lymphocyte protein 4 (CTLA4) is a protein from Homo sapiens identified by UniProt accession P16410, 223 residues long. MolForge cross-references it against 0 known binders and 1,297 disease associations.

Target properties

Protein name	Cytotoxic T-lymphocyte protein 4
UniProt accession	P16410
Gene	CTLA4
Organism	Homo sapiens
Length	223 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (2)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (1297)

Diseases linked to this target (Open Targets).

autoimmune lymphoproliferative syndrome due to CTLA4 haploinsufficiency · score 0.79
celiac disease · score 0.60
type 1 diabetes mellitus · score 0.59
melanoma · score 0.59
non-small cell lung carcinoma · score 0.55
renal cell carcinoma · score 0.55
metastatic melanoma · score 0.54
hepatocellular carcinoma · score 0.54
common variable immunodeficiency · score 0.54
systemic lupus erythematosus · score 0.53

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P16410-F1	alphafold	PREDICTED	80.13	—

Amino-acid sequence (223 residues)

MACLGFQRHK AQLNLATRTW PCTLLFFLLF IPVFCKAMHV AQPAVVLASS RGIASFVCEY ASPGKATEVR VTVLRQADSQ VTEVCAATYM MGNELTFLDD SICTGTSSGN QVNLTIQGLR AMDTGLYICK VELMYPPPYY LGIGNGTQIY VIDPEPCPDS DFLLWILAAV SSGLFFYSFL LTAVSLSKML KKRSPLTTGV YVKMPPTEPE CEKQFQPYFI PIN

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards