Epithelial cell adhesion molecule (EPCAM)

About Epithelial cell adhesion molecule

Epithelial cell adhesion molecule (EPCAM) is a protein from Homo sapiens identified by UniProt accession P16422, 314 residues long. MolForge cross-references it against 0 known binders and 621 disease associations.

Target properties

Protein name	Epithelial cell adhesion molecule
UniProt accession	P16422
Gene	EPCAM
Organism	Homo sapiens
Length	314 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (1)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (621)

Diseases linked to this target (Open Targets).

congenital diarrhea 5 with tufting enteropathy · score 0.73
Lynch syndrome 8 · score 0.72
Intestinal epithelial dysplasia · score 0.71
gastric cancer · score 0.54
hereditary nonpolyposis colorectal carcinoma · score 0.52
Lynch syndrome · score 0.50
neoplasm · score 0.50
colon carcinoma · score 0.43
hereditary neoplastic syndrome · score 0.42
Inherited cancer-predisposing syndrome · score 0.42

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P16422-F1	alphafold	PREDICTED	87.20	—

Amino-acid sequence (314 residues)

MAPPQVLAFG LLLAAATATF AAAQEECVCE NYKLAVNCFV NNNRQCQCTS VGAQNTVICS KLAAKCLVMK AEMNGSKLGR RAKPEGALQN NDGLYDPDCD ESGLFKAKQC NGTSMCWCVN TAGVRRTDKD TEITCSERVR TYWIIIELKH KAREKPYDSK SLRTALQKEI TTRYQLDPKF ITSILYENNV ITIDLVQNSS QKTQNDVDIA DVAYYFEKDV KGESLFHSKK MDLTVNGEQL DLDPGQTLIY YVDEKAPEFS MQGLKAGVIA VIVVVVIAVV AGIVVLVISR KKRMAKYEKA EIKEMGEMHR ELNA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards