About NADPH--cytochrome P450 reductase
NADPH--cytochrome P450 reductase (POR) is a protein
from Homo sapiens identified by UniProt accession
P16435, 677 residues long.
MolForge cross-references it against 0 known binders and
189 disease associations.
Target properties
| Protein name | NADPH--cytochrome P450 reductase |
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| UniProt accession | P16435 |
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| Gene | POR |
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| Organism | Homo sapiens |
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| Length | 677 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (189)
Diseases linked to this target (Open Targets).
- Antley-Bixler syndrome with genital anomalies and disordered steroidogenesis · score 0.81
- congenital adrenal hyperplasia due to cytochrome P450 oxidoreductase deficiency · score 0.80
- congenital adrenal hyperplasia · score 0.57
- testosterone measurement · score 0.50
- tea consumption measurement · score 0.50
- Antley-Bixler syndrome without genital anomalies or disordered steroidogenesis · score 0.49
- neuroinflammatory disorder · score 0.31
- NADPH--cytochrome P450 reductase measurement · score 0.31
- platelet count · score 0.30
- triglyceride measurement · score 0.29
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P16435-F1 | alphafold | PREDICTED | 91.05 | — |
Amino-acid sequence (677 residues)
MGDSHVDTSS TVSEAVAEEV SLFSMTDMIL FSLIVGLLTY WFLFRKKKEE VPEFTKIQTL TSSVRESSFV EKMKKTGRNI IVFYGSQTGT AEEFANRLSK DAHRYGMRGM SADPEEYDLA DLSSLPEIDN ALVVFCMATY GEGDPTDNAQ DFYDWLQETD VDLSGVKFAV FGLGNKTYEH FNAMGKYVDK RLEQLGAQRI FELGLGDDDG NLEEDFITWR EQFWPAVCEH FGVEATGEES SIRQYELVVH TDIDAAKVYM GEMGRLKSYE NQKPPFDAKN PFLAAVTTNR KLNQGTERHL MHLELDISDS KIRYESGDHV AVYPANDSAL VNQLGKILGA DLDVVMSLNN LDEESNKKHP FPCPTSYRTA LTYYLDITNP PRTNVLYELA QYASEPSEQE LLRKMASSSG EGKELYLSWV VEARRHILAI LQDCPSLRPP IDHLCELLPR LQARYYSIAS SSKVHPNSVH ICAVVVEYET KAGRINKGVA TNWLRAKEPA GENGGRALVP MFVRKSQFRL PFKATTPVIM VGPGTGVAPF IGFIQERAWL RQQGKEVGET LLYYGCRRSD EDYLYREELA QFHRDGALTQ LNVAFSREQS HKVYVQHLLK QDREHLWKLI EGGAHIYVCG DARNMARDVQ NTFYDIVAEL GAMEHAQAVD YIKKLMTKGR YSLDVWS
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