Dipeptidase 1 (DPEP1)

About Dipeptidase 1

Dipeptidase 1 (DPEP1) is a protein from Homo sapiens identified by UniProt accession P16444, 411 residues long. MolForge cross-references it against 0 known binders and 183 disease associations.

Target properties

Protein name	Dipeptidase 1
UniProt accession	P16444
Gene	DPEP1
Organism	Homo sapiens
Length	411 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (1)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (183)

Diseases linked to this target (Open Targets).

infection · score 0.60
urinary tract infection · score 0.59
Sepsis · score 0.59
pneumonia · score 0.59
endocarditis · score 0.58
body height · score 0.45
diastolic blood pressure · score 0.44
serum metabolite measurement · score 0.40
bacterial pneumonia · score 0.36
urinary metabolite measurement · score 0.33

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P16444-F1	alphafold	PREDICTED	93.32	—

Amino-acid sequence (411 residues)

MWSGWWLWPL VAVCTADFFR DEAERIMRDS PVIDGHNDLP WQLLDMFNNR LQDERANLTT LAGTHTNIPK LRAGFVGGQF WSVYTPCDTQ NKDAVRRTLE QMDVVHRMCR MYPETFLYVT SSAGIRQAFR EGKVASLIGV EGGHSIDSSL GVLRALYQLG MRYLTLTHSC NTPWADNWLV DTGDSEPQSQ GLSPFGQRVV KELNRLGVLI DLAHVSVATM KATLQLSRAP VIFSHSSAYS VCASRRNVPD DVLRLVKQTD SLVMVNFYNN YISCTNKANL SQVADHLDHI KEVAGARAVG FGGDFDGVPR VPEGLEDVSK YPDLIAELLR RNWTEAEVKG ALADNLLRVF EAVEQASNLT QAPEEEPIPL DQLGGSCRTH YGYSSGASSL HRHWGLLLAS LAPLVLCLSL L

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards