About Methylated-DNA--protein-cysteine methyltransferase
Methylated-DNA--protein-cysteine methyltransferase (MGMT) is a protein
from Homo sapiens identified by UniProt accession
P16455, 207 residues long.
MolForge cross-references it against 0 known binders and
559 disease associations.
Target properties
| Protein name | Methylated-DNA--protein-cysteine methyltransferase |
|---|
| UniProt accession | P16455 |
|---|
| Gene | MGMT |
|---|
| Organism | Homo sapiens |
|---|
| Length | 207 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (559)
Diseases linked to this target (Open Targets).
- heel bone mineral density · score 0.47
- body height · score 0.47
- bone quantitative ultrasound measurement · score 0.41
- chronotype measurement · score 0.35
- brain measurement · score 0.32
- anorexia nervosa · score 0.32
- cystatin C measurement · score 0.31
- creatinine measurement · score 0.30
- gene methylation measurement · score 0.28
- response to temozolomide · score 0.28
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P16455-F1 | alphafold | PREDICTED | 85.13 | — |
Amino-acid sequence (207 residues)
MDKDCEMKRT TLDSPLGKLE LSGCEQGLHE IKLLGKGTSA ADAVEVPAPA AVLGGPEPLM QCTAWLNAYF HQPEAIEEFP VPALHHPVFQ QESFTRQVLW KLLKVVKFGE VISYQQLAAL AGNPKAARAV GGAMRGNPVP ILIPCHRVVC SSGAVGNYSG GLAVKEWLLA HEGHRLGKPG LGGSSGLAGA WLKGAGATSG SPPAGRN
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