About Prolactin receptor
Prolactin receptor (PRLR) is a protein
from Homo sapiens identified by UniProt accession
P16471, 622 residues long.
MolForge cross-references it against 0 known binders and
358 disease associations.
Target properties
| Protein name | Prolactin receptor |
|---|
| UniProt accession | P16471 |
|---|
| Gene | PRLR |
|---|
| Organism | Homo sapiens |
|---|
| Length | 622 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (358)
Diseases linked to this target (Open Targets).
- familial hyperprolactinemia · score 0.60
- testosterone measurement · score 0.44
- appendicular lean mass · score 0.41
- breast carcinoma · score 0.40
- multiple fibroadenoma of the breast · score 0.40
- Familial hyperprolactinemia · score 0.37
- urate measurement · score 0.33
- chronotype measurement · score 0.29
- IGF-1 measurement · score 0.29
- multiple sclerosis · score 0.29
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P16471-F1 | alphafold | PREDICTED | 61.02 | — |
Amino-acid sequence (622 residues)
MKENVASATV FTLLLFLNTC LLNGQLPPGK PEIFKCRSPN KETFTCWWRP GTDGGLPTNY SLTYHREGET LMHECPDYIT GGPNSCHFGK QYTSMWRTYI MMVNATNQMG SSFSDELYVD VTYIVQPDPP LELAVEVKQP EDRKPYLWIK WSPPTLIDLK TGWFTLLYEI RLKPEKAAEW EIHFAGQQTE FKILSLHPGQ KYLVQVRCKP DHGYWSAWSP ATFIQIPSDF TMNDTTVWIS VAVLSAVICL IIVWAVALKG YSMVTCIFPP VPGPKIKGFD AHLLEKGKSE ELLSALGCQD FPPTSDYEDL LVEYLEVDDS EDQHLMSVHS KEHPSQGMKP TYLDPDTDSG RGSCDSPSLL SEKCEEPQAN PSTFYDPEVI EKPENPETTH TWDPQCISME GKIPYFHAGG SKCSTWPLPQ PSQHNPRSSY HNITDVCELA VGPAGAPATL LNEAGKDALK SSQTIKSREE GKATQQREVE SFHSETDQDT PWLLPQEKTP FGSAKPLDYV EIHKVNKDGA LSLLPKQREN SGKPKKPGTP ENNKEYAKVS GVMDNNILVL VPDPHAKNVA CFEESAKEAP PSLEQNQAEK ALANFTATSS KCRLQLGGLD YLDPACFTHS FH
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