About Thyrotropin receptor
Thyrotropin receptor (TSHR) is a protein
from Homo sapiens identified by UniProt accession
P16473, 764 residues long.
MolForge cross-references it against 0 known binders and
512 disease associations.
Target properties
| Protein name | Thyrotropin receptor |
|---|
| UniProt accession | P16473 |
|---|
| Gene | TSHR |
|---|
| Organism | Homo sapiens |
|---|
| Length | 764 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (512)
Diseases linked to this target (Open Targets).
- hypothyroidism due to TSH receptor mutations · score 0.80
- hypothyroidism · score 0.73
- familial gestational hyperthyroidism · score 0.72
- familial hyperthyroidism due to mutations in TSH receptor · score 0.72
- thyroid disease · score 0.68
- drug use measurement · score 0.60
- myxedema · score 0.59
- thyroid neoplasm · score 0.54
- Graves disease · score 0.52
- thyroid cancer · score 0.50
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P16473-F1 | alphafold | PREDICTED | 74.01 | — |
Amino-acid sequence (764 residues)
MRPADLLQLV LLLDLPRDLG GMGCSSPPCE CHQEEDFRVT CKDIQRIPSL PPSTQTLKLI ETHLRTIPSH AFSNLPNISR IYVSIDVTLQ QLESHSFYNL SKVTHIEIRN TRNLTYIDPD ALKELPLLKF LGIFNTGLKM FPDLTKVYST DIFFILEITD NPYMTSIPVN AFQGLCNETL TLKLYNNGFT SVQGYAFNGT KLDAVYLNKN KYLTVIDKDA FGGVYSGPSL LDVSQTSVTA LPSKGLEHLK ELIARNTWTL KKLPLSLSFL HLTRADLSYP SHCCAFKNQK KIRGILESLM CNESSMQSLR QRKSVNALNS PLHQEYEENL GDSIVGYKEK SKFQDTHNNA HYYVFFEEQE DEIIGFGQEL KNPQEETLQA FDSHYDYTIC GDSEDMVCTP KSDEFNPCED IMGYKFLRIV VWFVSLLALL GNVFVLLILL TSHYKLNVPR FLMCNLAFAD FCMGMYLLLI ASVDLYTHSE YYNHAIDWQT GPGCNTAGFF TVFASELSVY TLTVITLERW YAITFAMRLD RKIRLRHACA IMVGGWVCCF LLALLPLVGI SSYAKVSICL PMDTETPLAL AYIVFVLTLN IVAFVIVCCC YVKIYITVRN PQYNPGDKDT KIAKRMAVLI FTDFICMAPI SFYALSAILN KPLITVSNSK ILLVLFYPLN SCANPFLYAI FTKAFQRDVF ILLSKFGICK RQAQAYRGQR VPPKNSTDIQ VQKVTHEMRQ GLHNMEDVYE LIENSHLTPK KQGQISEEYM QTVL
Explore Thyrotropin receptor with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets