About Neuroendocrine convertase 2
Neuroendocrine convertase 2 (PCSK2) is a protein
from Homo sapiens identified by UniProt accession
P16519, 638 residues long.
MolForge cross-references it against 0 known binders and
192 disease associations.
Target properties
| Protein name | Neuroendocrine convertase 2 |
|---|
| UniProt accession | P16519 |
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| Gene | PCSK2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 638 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (192)
Diseases linked to this target (Open Targets).
- age at menarche · score 0.43
- chronotype measurement · score 0.39
- body mass index · score 0.38
- self reported educational attainment · score 0.34
- wellbeing measurement · score 0.34
- cortical surface area measurement · score 0.27
- body weight · score 0.26
- protein measurement · score 0.25
- neuroimaging measurement · score 0.25
- neuroinflammatory disorder · score 0.23
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P16519-F1 | alphafold | PREDICTED | 92.48 | — |
Amino-acid sequence (638 residues)
MKGGCVSQWK AAAGFLFCVM VFASAERPVF TNHFLVELHK GGEDKARQVA AEHGFGVRKL PFAEGLYHFY HNGLAKAKRR RSLHHKQQLE RDPRVKMALQ QEGFDRKKRG YRDINEIDIN MNDPLFTKQW YLINTGQADG TPGLDLNVAE AWELGYTGKG VTIGIMDDGI DYLHPDLASN YNAEASYDFS SNDPYPYPRY TDDWFNSHGT RCAGEVSAAA NNNICGVGVA YNSKVAGIRM LDQPFMTDII EASSISHMPQ LIDIYSASWG PTDNGKTVDG PRELTLQAMA DGVNKGRGGK GSIYVWASGD GGSYDDCNCD GYASSMWTIS INSAINDGRT ALYDESCSST LASTFSNGRK RNPEAGVATT DLYGNCTLRH SGTSAAAPEA AGVFALALEA NLGLTWRDMQ HLTVLTSKRN QLHDEVHQWR RNGVGLEFNH LFGYGVLDAG AMVKMAKDWK TVPERFHCVG GSVQDPEKIP STGKLVLTLT TDACEGKENF VRYLEHVQAV ITVNATRRGD LNINMTSPMG TKSILLSRRP RDDDSKVGFD KWPFMTTHTW GEDARGTWTL ELGFVGSAPQ KGVLKEWTLM LHGTQSAPYI DQVVRDYQSK LAMSKKEELE EELDEAVERS LKSILNKN
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