Guanine nucleotide-binding protein G(I)/G(S)/G(T)…

About Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 (GNB3) is a protein from Homo sapiens identified by UniProt accession P16520, 340 residues long. MolForge cross-references it against 0 known binders and 176 disease associations.

Target properties

Protein name	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
UniProt accession	P16520
Gene	GNB3
Organism	Homo sapiens
Length	340 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (176)

Diseases linked to this target (Open Targets).

congenital stationary night blindness 1H · score 0.68
congenital stationary night blindness · score 0.37
endometrial cancer · score 0.28
breast adenocarcinoma · score 0.28
head and neck squamous cell carcinoma · score 0.26
Myopia · score 0.24
lung adenocarcinoma · score 0.23
Abnormality of refraction · score 0.23
refractive error · score 0.21
refractive error measurement · score 0.21

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P16520-F1	alphafold	PREDICTED	97.18	—

Amino-acid sequence (340 residues)

MGEMEQLRQE AEQLKKQIAD ARKACADVTL AELVSGLEVV GRVQMRTRRT LRGHLAKIYA MHWATDSKLL VSASQDGKLI VWDSYTTNKV HAIPLRSSWV MTCAYAPSGN FVACGGLDNM CSIYNLKSRE GNVKVSRELS AHTGYLSCCR FLDDNNIVTS SGDTTCALWD IETGQQKTVF VGHTGDCMSL AVSPDFNLFI SGACDASAKL WDVREGTCRQ TFTGHESDIN AICFFPNGEA ICTGSDDASC RLFDLRADQE LICFSHESII CGITSVAFSL SGRLLFAGYD DFNCNVWDSM KSERVGILSG HDNRVSCLGV TADGMAVATG SWDSFLKIWN

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 (GNB3)