Cysteine-rich secretory protein 2 (CRISP2)

About Cysteine-rich secretory protein 2

Cysteine-rich secretory protein 2 (CRISP2) is a protein from Homo sapiens identified by UniProt accession P16562, 243 residues long. MolForge cross-references it against 0 known binders and 92 disease associations.

Target properties

Protein name	Cysteine-rich secretory protein 2
UniProt accession	P16562
Gene	CRISP2
Organism	Homo sapiens
Length	243 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (92)

Diseases linked to this target (Open Targets).

PHF-tau measurement · score 0.16
gut microbiome measurement · score 0.15
Aganglionic megacolon · score 0.12
azoospermia · score 0.08
male infertility with teratozoospermia due to single gene mutation · score 0.08
spermatogenic failure 55 · score 0.06
spermatogenic failure 3 · score 0.06
spermatogenic failure 7 · score 0.06
glucuronate measurement · score 0.06
spermatogenic failure 29 · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P16562-F1	alphafold	PREDICTED	93.07	—

Amino-acid sequence (243 residues)

MALLPVLFLV TVLLPSLPAE GKDPAFTALL TTQLQVQREI VNKHNELRKA VSPPASNMLK MEWSREVTTN AQRWANKCTL QHSDPEDRKT STRCGENLYM SSDPTSWSSA IQSWYDEILD FVYGVGPKSP NAVVGHYTQL VWYSTYQVGC GIAYCPNQDS LKYYYVCQYC PAGNNMNRKN TPYQQGTPCA GCPDDCDKGL CTNSCQYQDL LSNCDSLKNT AGCEHELLKE KCKATCLCEN KIY

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards