About E-selectin
E-selectin (SELE) is a protein
from Homo sapiens identified by UniProt accession
P16581, 610 residues long.
MolForge cross-references it against 0 known binders and
810 disease associations.
Target properties
| Protein name | E-selectin |
|---|
| UniProt accession | P16581 |
|---|
| Gene | SELE |
|---|
| Organism | Homo sapiens |
|---|
| Length | 610 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (810)
Diseases linked to this target (Open Targets).
- acute myeloid leukemia · score 0.36
- sickle cell anemia · score 0.27
- monocyte count · score 0.26
- blood protein measurement · score 0.25
- e-selectin measurement · score 0.25
- glioblastoma multiforme · score 0.19
- myeloid white cell count · score 0.18
- breast adenocarcinoma · score 0.18
- alkaline phosphatase measurement · score 0.18
- age at menopause · score 0.17
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P16581-F1 | alphafold | PREDICTED | 83.02 | — |
Amino-acid sequence (610 residues)
MIASQFLSAL TLVLLIKESG AWSYNTSTEA MTYDEASAYC QQRYTHLVAI QNKEEIEYLN SILSYSPSYY WIGIRKVNNV WVWVGTQKPL TEEAKNWAPG EPNNRQKDED CVEIYIKREK DVGMWNDERC SKKKLALCYT AACTNTSCSG HGECVETINN YTCKCDPGFS GLKCEQIVNC TALESPEHGS LVCSHPLGNF SYNSSCSISC DRGYLPSSME TMQCMSSGEW SAPIPACNVV ECDAVTNPAN GFVECFQNPG SFPWNTTCTF DCEEGFELMG AQSLQCTSSG NWDNEKPTCK AVTCRAVRQP QNGSVRCSHS PAGEFTFKSS CNFTCEEGFM LQGPAQVECT TQGQWTQQIP VCEAFQCTAL SNPERGYMNC LPSASGSFRY GSSCEFSCEQ GFVLKGSKRL QCGPTGEWDN EKPTCEAVRC DAVHQPPKGL VRCAHSPIGE FTYKSSCAFS CEEGFELHGS TQLECTSQGQ WTEEVPSCQV VKCSSLAVPG KINMSCSGEP VFGTVCKFAC PEGWTLNGSA ARTCGATGHW SGLLPTCEAP TESNIPLVAG LSAAGLSLLT LAPFLLWLRK CLRKAKKFVP ASSCQSLESD GSYQKPSYIL
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