Natriuretic peptides B (NPPB)

About Natriuretic peptides B

Natriuretic peptides B (NPPB) is a protein from Homo sapiens identified by UniProt accession P16860, 134 residues long. MolForge cross-references it against 0 known binders and 1,071 disease associations.

Target properties

Protein name	Natriuretic peptides B
UniProt accession	P16860
Gene	NPPB
Organism	Homo sapiens
Length	134 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (1071)

Diseases linked to this target (Open Targets).

smoking status measurement · score 0.29
diastolic blood pressure · score 0.28
systolic blood pressure · score 0.28
body mass index · score 0.26
BNP measurement · score 0.25
N-terminal prohormone brain natriuretic peptide measurement · score 0.25
alcohol drinking · score 0.24
pulse pressure measurement · score 0.24
blood protein measurement · score 0.22
neurodegenerative disease · score 0.22

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P16860-F1	alphafold	PREDICTED	60.01	—

Amino-acid sequence (134 residues)

MDPQTAPSRA LLLLLFLHLA FLGGRSHPLG SPGSASDLET SGLQEQRNHL QGKLSELQVE QTSLEPLQES PRPTGVWKSR EVATEGIRGH RKMVLYTLRA PRSPKMVQGS GCFGRKMDRI SSSSGLGCKV LRRH

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards