Carboxypeptidase E (CPE)

About Carboxypeptidase E

Carboxypeptidase E (CPE) is a protein from Homo sapiens identified by UniProt accession P16870, 476 residues long. MolForge cross-references it against 0 known binders and 357 disease associations.

Target properties

Protein name	Carboxypeptidase E
UniProt accession	P16870
Gene	CPE
Organism	Homo sapiens
Length	476 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (357)

Diseases linked to this target (Open Targets).

BDV syndrome · score 0.65
vital capacity · score 0.49
body height · score 0.46
genetic disorder · score 0.41
PHF-tau measurement · score 0.34
atopic eczema · score 0.34
neurodegenerative disease · score 0.31
sitting height measurement · score 0.31
forced expiratory volume · score 0.30
heel bone mineral density · score 0.28

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P16870-F1	alphafold	PREDICTED	90.36	—

Amino-acid sequence (476 residues)

MAGRGGSALL ALCGALAACG WLLGAEAQEP GAPAAGMRRR RRLQQEDGIS FEYHRYPELR EALVSVWLQC TAISRIYTVG RSFEGRELLV IELSDNPGVH EPGEPEFKYI GNMHGNEAVG RELLIFLAQY LCNEYQKGNE TIVNLIHSTR IHIMPSLNPD GFEKAASQPG ELKDWFVGRS NAQGIDLNRN FPDLDRIVYV NEKEGGPNNH LLKNMKKIVD QNTKLAPETK AVIHWIMDIP FVLSANLHGG DLVANYPYDE TRSGSAHEYS SSPDDAIFQS LARAYSSFNP AMSDPNRPPC RKNDDDSSFV DGTTNGGAWY SVPGGMQDFN YLSSNCFEIT VELSCEKFPP EETLKTYWED NKNSLISYLE QIHRGVKGFV RDLQGNPIAN ATISVEGIDH DVTSAKDGDY WRLLIPGNYK LTASAPGYLA ITKKVAVPYS PAAGVDFELE SFSERKEEEK EELMEWWKMM SETLNF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards