Interleukin-7 receptor subunit alpha (IL7R)

About Interleukin-7 receptor subunit alpha

Interleukin-7 receptor subunit alpha (IL7R) is a protein from Homo sapiens identified by UniProt accession P16871, 459 residues long. MolForge cross-references it against 0 known binders and 764 disease associations.

Target properties

Protein name	Interleukin-7 receptor subunit alpha
UniProt accession	P16871
Gene	IL7R
Organism	Homo sapiens
Length	459 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (764)

Diseases linked to this target (Open Targets).

immunodeficiency 104 · score 0.80
T-B+ severe combined immunodeficiency due to JAK3 deficiency · score 0.60
Omenn syndrome · score 0.56
severe combined immunodeficiency · score 0.52
lymphocyte count · score 0.50
multiple sclerosis · score 0.49
blood protein measurement · score 0.48
leukocyte count · score 0.46
T-B+ severe combined immunodeficiency · score 0.46
T-B+ severe combined immunodeficiency due to IL-7Ralpha deficiency · score 0.46

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P16871-F1	alphafold	PREDICTED	67.46	—

Amino-acid sequence (459 residues)

MTILGTTFGM VFSLLQVVSG ESGYAQNGDL EDAELDDYSF SCYSQLEVNG SQHSLTCAFE DPDVNITNLE FEICGALVEV KCLNFRKLQE IYFIETKKFL LIGKSNICVK VGEKSLTCKK IDLTTIVKPE APFDLSVVYR EGANDFVVTF NTSHLQKKYV KVLMHDVAYR QEKDENKWTH VNLSSTKLTL LQRKLQPAAM YEIKVRSIPD HYFKGFWSEW SPSYYFRTPE INNSSGEMDP ILLTISILSF FSVALLVILA CVLWKKRIKP IVWPSLPDHK KTLEHLCKKP RKNLNVSFNP ESFLDCQIHR VDDIQARDEV EGFLQDTFPQ QLEESEKQRL GGDVQSPNCP SEDVVITPES FGRDSSLTCL AGNVSACDAP ILSSSRSLDC RESGKNGPHV YQDLLLSLGT TNSTLPPPFS LQSGILTLNP VAQGQPILTS LGSNQEEAYV TMSSFYQNQ

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards