Fumarylacetoacetase (FAH)

About Fumarylacetoacetase

Fumarylacetoacetase (FAH) is a protein from Homo sapiens identified by UniProt accession P16930, 419 residues long. MolForge cross-references it against 0 known binders and 233 disease associations.

Target properties

Protein name	Fumarylacetoacetase
UniProt accession	P16930
Gene	FAH
Organism	Homo sapiens
Length	419 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (233)

Diseases linked to this target (Open Targets).

tyrosinemia type I · score 0.81
Tyrosinemia type 1 · score 0.80
Cholestasis · score 0.46
cholestasis · score 0.46
mean platelet volume · score 0.36
T-substance anomaly · score 0.34
tyrosinemia type II · score 0.34
Tyrosinemia type 2 · score 0.34
beta-mannosidosis · score 0.27
genetic disorder · score 0.19

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P16930-F1	alphafold	PREDICTED	98.05	—

Amino-acid sequence (419 residues)

MSFIPVAEDS DFPIHNLPYG VFSTRGDPRP RIGVAIGDQI LDLSIIKHLF TGPVLSKHQD VFNQPTLNSF MGLGQAAWKE ARVFLQNLLS VSQARLRDDT ELRKCAFISQ ASATMHLPAT IGDYTDFYSS RQHATNVGIM FRDKENALMP NWLHLPVGYH GRASSVVVSG TPIRRPMGQM KPDDSKPPVY GACKLLDMEL EMAFFVGPGN RLGEPIPISK AHEHIFGMVL MNDWSARDIQ KWEYVPLGPF LGKSFGTTVS PWVVPMDALM PFAVPNPKQD PRPLPYLCHD EPYTFDINLS VNLKGEGMSQ AATICKSNFK YMYWTMLQQL THHSVNGCNL RPGDLLASGT ISGPEPENFG SMLELSWKGT KPIDLGNGQT RKFLLDGDEV IITGYCQGDG YRIGFGQCAG KVLPALLPS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards