Y-box-binding protein 3 (YBX3)

About Y-box-binding protein 3

Y-box-binding protein 3 (YBX3) is a protein from Homo sapiens identified by UniProt accession P16989, 372 residues long. MolForge cross-references it against 0 known binders and 221 disease associations.

Target properties

Protein name	Y-box-binding protein 3
UniProt accession	P16989
Gene	YBX3
Organism	Homo sapiens
Length	372 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (221)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.31
Vasodilators used in cardiac diseases use measurement · score 0.22
age at menopause · score 0.22
Abnormality of refraction · score 0.20
coronary artery disease · score 0.18
menopause · score 0.17
azoospermia · score 0.10
partial chromosome Y deletion · score 0.08
breast cancer · score 0.08
cancer · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P16989-F1	alphafold	PREDICTED	59.29	—

Amino-acid sequence (372 residues)

MSEAGEATTT TTTTLPQAPT EAAAAAPQDP APKSPVGSGA PQAAAPAPAA HVAGNPGGDA APAATGTAAA ASLATAAGSE DAEKKVLATK VLGTVKWFNV RNGYGFINRN DTKEDVFVHQ TAIKKNNPRK YLRSVGDGET VEFDVVEGEK GAEAANVTGP DGVPVEGSRY AADRRRYRRG YYGRRRGPPR NYAGEEEEEG SGSSEGFDPP ATDRQFSGAR NQLRRPQYRP QYRQRRFPPY HVGQTFDRRS RVLPHPNRIQ AGEIGEMKDG VPEGAQLQGP VHRNPTYRPR YRSRGPPRPR PAPAVGEAED KENQQATSGP NQPSVRRGYR RPYNYRRRPR PPNAPSQDGK EAKAGEAPTE NPAPPTQQSS AE

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards