Alpha-N-acetylgalactosaminidase (NAGA)

About Alpha-N-acetylgalactosaminidase

Alpha-N-acetylgalactosaminidase (NAGA) is a protein from Homo sapiens identified by UniProt accession P17050, 411 residues long. MolForge cross-references it against 0 known binders and 91 disease associations.

Target properties

Protein name	Alpha-N-acetylgalactosaminidase
UniProt accession	P17050
Gene	NAGA
Organism	Homo sapiens
Length	411 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (91)

Diseases linked to this target (Open Targets).

alpha-N-acetylgalactosaminidase deficiency type 2 · score 0.80
alpha-N-acetylgalactosaminidase deficiency type 1 · score 0.79
alpha-N-acetylgalactosaminidase deficiency · score 0.72
alpha-N-acetylgalactosaminidase deficiency type 3 · score 0.65
genetic disorder · score 0.41
Seizure · score 0.37
neurodegenerative disease · score 0.35
schizophrenia · score 0.17
autism spectrum disorder · score 0.14
bipolar disorder · score 0.14

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P17050-F1	alphafold	PREDICTED	96.07	—

Amino-acid sequence (411 residues)

MLLKTVLLLG HVAQVLMLDN GLLQTPPMGW LAWERFRCNI NCDEDPKNCI SEQLFMEMAD RMAQDGWRDM GYTYLNIDDC WIGGRDASGR LMPDPKRFPH GIPFLADYVH SLGLKLGIYA DMGNFTCMGY PGTTLDKVVQ DAQTFAEWKV DMLKLDGCFS TPEERAQGYP KMAAALNATG RPIAFSCSWP AYEGGLPPRV NYSLLADICN LWRNYDDIQD SWWSVLSILN WFVEHQDILQ PVAGPGHWND PDMLLIGNFG LSLEQSRAQM ALWTVLAAPL LMSTDLRTIS AQNMDILQNP LMIKINQDPL GIQGRRIHKE KSLIEVYMRP LSNKASALVF FSCRTDMPYR YHSSLGQLNF TGSVIYEAQD VYSGDIISGL RDETNFTVII NPSGVVMWYL YPIKNLEMSQ Q

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards