About Heat shock 70 kDa protein 6
Heat shock 70 kDa protein 6 (HSPA6) is a protein
from Homo sapiens identified by UniProt accession
P17066, 643 residues long.
MolForge cross-references it against 0 known binders and
100 disease associations.
Target properties
| Protein name | Heat shock 70 kDa protein 6 |
|---|
| UniProt accession | P17066 |
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| Gene | HSPA6 |
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| Organism | Homo sapiens |
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| Length | 643 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (100)
Diseases linked to this target (Open Targets).
- blood protein measurement · score 0.30
- leukocyte count · score 0.30
- erythrocyte count · score 0.27
- total blood protein measurement · score 0.20
- systemic lupus erythematosus · score 0.18
- Takayasu arteritis · score 0.18
- platelet component distribution width · score 0.17
- serum albumin measurement · score 0.17
- total cholesterol measurement · score 0.16
- low affinity immunoglobulin gamma Fc region receptor II-a/b measurement · score 0.14
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P17066-F1 | alphafold | PREDICTED | 88.62 | — |
Amino-acid sequence (643 residues)
MQAPRELAVG IDLGTTYSCV GVFQQGRVEI LANDQGNRTT PSYVAFTDTE RLVGDAAKSQ AALNPHNTVF DAKRLIGRKF ADTTVQSDMK HWPFRVVSEG GKPKVRVCYR GEDKTFYPEE ISSMVLSKMK ETAEAYLGQP VKHAVITVPA YFNDSQRQAT KDAGAIAGLN VLRIINEPTA AAIAYGLDRR GAGERNVLIF DLGGGTFDVS VLSIDAGVFE VKATAGDTHL GGEDFDNRLV NHFMEEFRRK HGKDLSGNKR ALRRLRTACE RAKRTLSSST QATLEIDSLF EGVDFYTSIT RARFEELCSD LFRSTLEPVE KALRDAKLDK AQIHDVVLVG GSTRIPKVQK LLQDFFNGKE LNKSINPDEA VAYGAAVQAA VLMGDKCEKV QDLLLLDVAP LSLGLETAGG VMTTLIQRNA TIPTKQTQTF TTYSDNQPGV FIQVYEGERA MTKDNNLLGR FELSGIPPAP RGVPQIEVTF DIDANGILSV TATDRSTGKA NKITITNDKG RLSKEEVERM VHEAEQYKAE DEAQRDRVAA KNSLEAHVFH VKGSLQEESL RDKIPEEDRR KMQDKCREVL AWLEHNQLAE KEEYEHQKRE LEQICRPIFS RLYGGPGVPG GSSCGTQARQ GDPSTGPIIE EVD
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