High mobility group protein HMG-I/HMG-Y (HMGA1)

About High mobility group protein HMG-I/HMG-Y

High mobility group protein HMG-I/HMG-Y (HMGA1) is a protein from Homo sapiens identified by UniProt accession P17096, 107 residues long. MolForge cross-references it against 0 known binders and 585 disease associations.

Target properties

Protein name	High mobility group protein HMG-I/HMG-Y
UniProt accession	P17096
Gene	HMGA1
Organism	Homo sapiens
Length	107 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (585)

Diseases linked to this target (Open Targets).

HIV infection · score 0.58
neurodegenerative disease · score 0.52
body height · score 0.38
head and neck squamous cell carcinoma · score 0.37
forced expiratory volume · score 0.37
carcinoma of liver and intrahepatic biliary tract · score 0.37
lean body mass · score 0.36
mean corpuscular volume · score 0.36
high density lipoprotein cholesterol measurement · score 0.35
vital capacity · score 0.35

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P17096-F1	alphafold	PREDICTED	65.03	—

Amino-acid sequence (107 residues)

MSESSSKSSQ PLASKQEKDG TEKRGRGRPR KQPPVSPGTA LVGSQKEPSE VPTPKRPRGR PKGSKNKGAA KTRKTTTTPG RKPRGRPKKL EKEEEEGISQ ESSEEEQ

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards