About Aspartate aminotransferase, cytoplasmic
Aspartate aminotransferase, cytoplasmic (GOT1) is a protein
from Homo sapiens identified by UniProt accession
P17174, 413 residues long.
MolForge cross-references it against 0 known binders and
337 disease associations.
Target properties
| Protein name | Aspartate aminotransferase, cytoplasmic |
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| UniProt accession | P17174 |
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| Gene | GOT1 |
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| Organism | Homo sapiens |
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| Length | 413 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (4)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (337)
Diseases linked to this target (Open Targets).
- aspartate aminotransferase measurement · score 0.69
- neurodegenerative disease · score 0.46
- Alzheimer disease · score 0.36
- lysosomal storage disease · score 0.36
- Parkinson disease · score 0.36
- multiple sclerosis · score 0.36
- Red cell distribution width · score 0.33
- monocyte percentage of leukocytes · score 0.22
- neoplasm · score 0.09
- endometrial cancer · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P17174-F1 | alphafold | PREDICTED | 96.35 | — |
Amino-acid sequence (413 residues)
MAPPSVFAEV PQAQPVLVFK LTADFREDPD PRKVNLGVGA YRTDDCHPWV LPVVKKVEQK IANDNSLNHE YLPILGLAEF RSCASRLALG DDSPALKEKR VGGVQSLGGT GALRIGADFL ARWYNGTNNK NTPVYVSSPT WENHNAVFSA AGFKDIRSYR YWDAEKRGLD LQGFLNDLEN APEFSIVVLH ACAHNPTGID PTPEQWKQIA SVMKHRFLFP FFDSAYQGFA SGNLERDAWA IRYFVSEGFE FFCAQSFSKN FGLYNERVGN LTVVGKEPES ILQVLSQMEK IVRITWSNPP AQGARIVAST LSNPELFEEW TGNVKTMADR ILTMRSELRA RLEALKTPGT WNHITDQIGM FSFTGLNPKQ VEYLVNEKHI YLLPSGRINV SGLTTKNLDY VATSIHEAVT KIQ
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