About Interferon alpha/beta receptor 1
Interferon alpha/beta receptor 1 (IFNAR1) is a protein
from Homo sapiens identified by UniProt accession
P17181, 557 residues long.
MolForge cross-references it against 0 known binders and
555 disease associations.
Target properties
| Protein name | Interferon alpha/beta receptor 1 |
|---|
| UniProt accession | P17181 |
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| Gene | IFNAR1 |
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| Organism | Homo sapiens |
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| Length | 557 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (555)
Diseases linked to this target (Open Targets).
- chronic hepatitis B virus infection · score 0.61
- hepatitis C virus infection · score 0.61
- neoplasm · score 0.61
- chronic hepatitis C virus infection · score 0.61
- multiple sclerosis · score 0.61
- relapsing-remitting multiple sclerosis · score 0.60
- melanoma · score 0.60
- hepatitis B virus infection · score 0.57
- COVID-19 · score 0.56
- polycythemia vera · score 0.56
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P17181-F1 | alphafold | PREDICTED | 78.02 | — |
Amino-acid sequence (557 residues)
MMVVLLGATT LVLVAVAPWV LSAAAGGKNL KSPQKVEVDI IDDNFILRWN RSDESVGNVT FSFDYQKTGM DNWIKLSGCQ NITSTKCNFS SLKLNVYEEI KLRIRAEKEN TSSWYEVDSF TPFRKAQIGP PEVHLEAEDK AIVIHISPGT KDSVMWALDG LSFTYSLVIW KNSSGVEERI ENIYSRHKIY KLSPETTYCL KVKAALLTSW KIGVYSPVHC IKTTVENELP PPENIEVSVQ NQNYVLKWDY TYANMTFQVQ WLHAFLKRNP GNHLYKWKQI PDCENVKTTQ CVFPQNVFQK GIYLLRVQAS DGNNTSFWSE EIKFDTEIQA FLLPPVFNIR SLSDSFHIYI GAPKQSGNTP VIQDYPLIYE IIFWENTSNA ERKIIEKKTD VTVPNLKPLT VYCVKARAHT MDEKLNKSSV FSDAVCEKTK PGNTSKIWLI VGICIALFAL PFVIYAAKVF LRCINYVFFP SLKPSSSIDE YFSEQPLKNL LLSTSEEQIE KCFIIENIST IATVEETNQT DEDHKKYSSQ TSQDSGNYSN EDESESKTSE ELQQDFV
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