Bactericidal permeability-increasing protein (BPI)

About Bactericidal permeability-increasing protein

Bactericidal permeability-increasing protein (BPI) is a protein from Homo sapiens identified by UniProt accession P17213, 487 residues long. MolForge cross-references it against 0 known binders and 222 disease associations.

Target properties

Protein name	Bactericidal permeability-increasing protein
UniProt accession	P17213
Gene	BPI
Organism	Homo sapiens
Length	487 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (222)

Diseases linked to this target (Open Targets).

blood protein measurement · score 0.47
monocyte count · score 0.39
protein measurement · score 0.31
basophil percentage of leukocytes · score 0.31
cerebrospinal fluid biomarker measurement · score 0.30
tumor necrosis factor measurement · score 0.28
monocyte percentage of leukocytes · score 0.28
basophil count · score 0.22
lung adenocarcinoma · score 0.18
ovarian cancer · score 0.18

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P17213-F1	alphafold	PREDICTED	92.47	—

Amino-acid sequence (487 residues)

MRENMARGPC NAPRWASLMV LVAIGTAVTA AVNPGVVVRI SQKGLDYASQ QGTAALQKEL KRIKIPDYSD SFKIKHLGKG HYSFYSMDIR EFQLPSSQIS MVPNVGLKFS ISNANIKISG KWKAQKRFLK MSGNFDLSIE GMSISADLKL GSNPTSGKPT ITCSSCSSHI NSVHVHISKS KVGWLIQLFH KKIESALRNK MNSQVCEKVT NSVSSELQPY FQTLPVMTKI DSVAGINYGL VAPPATTAET LDVQMKGEFY SENHHNPPPF APPVMEFPAA HDRMVYLGLS DYFFNTAGLV YQEAGVLKMT LRDDMIPKES KFRLTTKFFG TFLPEVAKKF PNMKIQIHVS ASTPPHLSVQ PTGLTFYPAV DVQAFAVLPN SSLASLFLIG MHTTGSMEVS AESNRLVGEL KLDRLLLELK HSNIGPFPVE LLQDIMNYIV PILVLPRVNE KLQKGFPLPT PARVQLYNVV LQPHQNFLLF GADVVYK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards