About Transcription factor JunB
Transcription factor JunB (JUNB) is a protein
from Homo sapiens identified by UniProt accession
P17275, 347 residues long.
MolForge cross-references it against 0 known binders and
72 disease associations.
Target properties
| Protein name | Transcription factor JunB |
|---|
| UniProt accession | P17275 |
|---|
| Gene | JUNB |
|---|
| Organism | Homo sapiens |
|---|
| Length | 347 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (72)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.46
- thyroid gland adenocarcinoma · score 0.23
- glioblastoma multiforme · score 0.19
- breast adenocarcinoma · score 0.18
- esophageal cancer · score 0.15
- diffuse large B-cell lymphoma · score 0.12
- monocyte count · score 0.08
- mean corpuscular volume · score 0.07
- mean corpuscular hemoglobin concentration · score 0.06
- glycoprotein storage disease · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P17275-F1 | alphafold | PREDICTED | 59.53 | — |
Amino-acid sequence (347 residues)
MCTKMEQPFY HDDSYTATGY GRAPGGLSLH DYKLLKPSLA VNLADPYRSL KAPGARGPGP EGGGGGSYFS GQGSDTGASL KLASSELERL IVPNSNGVIT TTPTPPGQYF YPRGGGSGGG AGGAGGGVTE EQEGFADGFV KALDDLHKMN HVTPPNVSLG ATGGPPAGPG GVYAGPEPPP VYTNLSSYSP ASASSGGAGA AVGTGSSYPT TTISYLPHAP PFAGGHPAQL GLGRGASTFK EEPQTVPEAR SRDATPPVSP INMEDQERIK VERKRLRNRL AATKCRKRKL ERIARLEDKV KTLKAENAGL SSTAGLLREQ VAQLKQKVMT HVSNGCQLLL GVKGHAF
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