Atrial natriuretic peptide receptor 3 (NPR3)

About Atrial natriuretic peptide receptor 3

Atrial natriuretic peptide receptor 3 (NPR3) is a protein from Homo sapiens identified by UniProt accession P17342, 541 residues long. MolForge cross-references it against 0 known binders and 518 disease associations.

Target properties

Protein name	Atrial natriuretic peptide receptor 3
UniProt accession	P17342
Gene	NPR3
Organism	Homo sapiens
Length	541 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (518)

Diseases linked to this target (Open Targets).

body height · score 0.72
BMI-adjusted waist circumference · score 0.63
lean body mass · score 0.62
Boudin-Mortier syndrome · score 0.58
systolic blood pressure · score 0.53
appendicular lean mass · score 0.53
hip circumference · score 0.52
forced expiratory volume · score 0.51
mean arterial pressure · score 0.50
diastolic blood pressure · score 0.49

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P17342-F1	alphafold	PREDICTED	84.07	—

Amino-acid sequence (541 residues)

MPSLLVLTFS PCVLLGWALL AGGTGGGGVG GGGGGAGIGG GRQEREALPP QKIEVLVLLP QDDSYLFSLT RVRPAIEYAL RSVEGNGTGR RLLPPGTRFQ VAYEDSDCGN RALFSLVDRV AAARGAKPDL ILGPVCEYAA APVARLASHW DLPMLSAGAL AAGFQHKDSE YSHLTRVAPA YAKMGEMMLA LFRHHHWSRA ALVYSDDKLE RNCYFTLEGV HEVFQEEGLH TSIYSFDETK DLDLEDIVRN IQASERVVIM CASSDTIRSI MLVAHRHGMT SGDYAFFNIE LFNSSSYGDG SWKRGDKHDF EAKQAYSSLQ TVTLLRTVKP EFEKFSMEVK SSVEKQGLNM EDYVNMFVEG FHDAILLYVL ALHEVLRAGY SKKDGGKIIQ QTWNRTFEGI AGQVSIDANG DRYGDFSVIA MTDVEAGTQE VIGDYFGKEG RFEMRPNVKY PWGPLKLRID ENRIVEHTNS SPCKSSGGLE ESAVTGIVVG ALLGAGLLMA FYFFRKKYRI TIERRTQQEE SNLGKHRELR EDSIRSHFSV A

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards