About Nucleolar transcription factor 1
Nucleolar transcription factor 1 (UBTF) is a protein
from Homo sapiens identified by UniProt accession
P17480, 764 residues long.
MolForge cross-references it against 0 known binders and
148 disease associations.
Target properties
| Protein name | Nucleolar transcription factor 1 |
|---|
| UniProt accession | P17480 |
|---|
| Gene | UBTF |
|---|
| Organism | Homo sapiens |
|---|
| Length | 764 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (148)
Diseases linked to this target (Open Targets).
- childhood-onset motor and cognitive regression syndrome with extrapyramidal movement disorder · score 0.71
- genetic disorder · score 0.41
- rare syndromic intellectual disability · score 0.34
- lymphocyte count · score 0.32
- body fat percentage · score 0.32
- mean corpuscular hemoglobin concentration · score 0.30
- sex hormone-binding globulin measurement · score 0.30
- neurodegenerative disease · score 0.29
- self reported educational attainment · score 0.27
- hemolysis · score 0.26
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P17480-F1 | alphafold | PREDICTED | 77.25 | — |
Amino-acid sequence (764 residues)
MNGEADCPTD LEMAAPKGQD RWSQEDMLTL LECMKNNLPS NDSSKFKTTE SHMDWEKVAF KDFSGDMCKL KWVEISNEVR KFRTLTELIL DAQEHVKNPY KGKKLKKHPD FPKKPLTPYF RFFMEKRAKY AKLHPEMSNL DLTKILSKKY KELPEKKKMK YIQDFQREKQ EFERNLARFR EDHPDLIQNA KKSDIPEKPK TPQQLWYTHE KKVYLKVRPD ATTKEVKDSL GKQWSQLSDK KRLKWIHKAL EQRKEYEEIM RDYIQKHPEL NISEEGITKS TLTKAERQLK DKFDGRPTKP PPNSYSLYCA ELMANMKDVP STERMVLCSQ QWKLLSQKEK DAYHKKCDQK KKDYEVELLR FLESLPEEEQ QRVLGEEKML NINKKQATSP ASKKPAQEGG KGGSEKPKRP VSAMFIFSEE KRRQLQEERP ELSESELTRL LARMWNDLSE KKKAKYKARE AALKAQSERK PGGEREERGK LPESPKRAEE IWQQSVIGDY LARFKNDRVK ALKAMEMTWN NMEKKEKLMW IKKAAEDQKR YERELSEMRA PPAATNSSKK MKFQGEPKKP PMNGYQKFSQ ELLSNGELNH LPLKERMVEI GSRWQRISQS QKEHYKKLAE EQQKQYKVHL DLWVKSLSPQ DRAAYKEYIS NKRKSMTKLR GPNPKSSRTT LQSKSESEED DEEDEDDEDE DEEEEDDENG DSSEDGGDSS ESSSEDESED GDENEEDDED EDDDEDDDED EDNESEGSSS SSSSSGDSSD SDSN
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