About Homeobox protein Hox-B8
Homeobox protein Hox-B8 (HOXB8) is a protein
from Homo sapiens identified by UniProt accession
P17481, 243 residues long.
MolForge cross-references it against 0 known binders and
175 disease associations.
Target properties
| Protein name | Homeobox protein Hox-B8 |
|---|
| UniProt accession | P17481 |
|---|
| Gene | HOXB8 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 243 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (175)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.20
- neoplasm · score 0.09
- autosomal recessive spondylocostal dysostosis · score 0.08
- cervical rib syndrome · score 0.08
- systolic blood pressure · score 0.07
- diastolic blood pressure · score 0.07
- pachyonychia congenita · score 0.07
- autosomal dominant spondylocostal dysostosis · score 0.07
- thoracolaryngopelvic dysplasia · score 0.07
- non-small cell lung carcinoma · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P17481-F1 | alphafold | PREDICTED | 63.57 | — |
Amino-acid sequence (243 residues)
MSSYFVNSLF SKYKTGESLR PNYYDCGFAQ DLGGRPTVVY GPSSGGSFQH PSQIQEFYHG PSSLSTAPYQ QNPCAVACHG DPGNFYGYDP LQRQSLFGAQ DPDLVQYADC KLAAASGLGE EAEGSEQSPS PTQLFPWMRP QAAAGRRRGR QTYSRYQTLE LEKEFLFNPY LTRKRRIEVS HALGLTERQV KIWFQNRRMK WKKENNKDKF PSSKCEQEEL EKQKLERAPE AADEGDAQKG DKK
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