About Homeobox protein Hox-B4
Homeobox protein Hox-B4 (HOXB4) is a protein
from Homo sapiens identified by UniProt accession
P17483, 251 residues long.
MolForge cross-references it against 0 known binders and
158 disease associations.
Target properties
| Protein name | Homeobox protein Hox-B4 |
|---|
| UniProt accession | P17483 |
|---|
| Gene | HOXB4 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 251 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (158)
Diseases linked to this target (Open Targets).
- head and neck squamous cell carcinoma · score 0.15
- dentures · score 0.13
- grip strength measurement · score 0.11
- dental caries · score 0.10
- hip bone mineral density · score 0.10
- neoplasm · score 0.09
- fat body mass · score 0.08
- autosomal recessive spondylocostal dysostosis · score 0.08
- systolic blood pressure · score 0.07
- erythrocyte count · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P17483-F1 | alphafold | PREDICTED | 66.18 | — |
Amino-acid sequence (251 residues)
MAMSSFLINS NYVDPKFPPC EEYSQSDYLP SDHSPGYYAG GQRRESSFQP EAGFGRRAAC TVQRYAACRD PGPPPPPPPP PPPPPPPGLS PRAPAPPPAG ALLPEPGQRC EAVSSSPPPP PCAQNPLHPS PSHSACKEPV VYPWMRKVHV STVNPNYAGG EPKRSRTAYT RQQVLELEKE FHYNRYLTRR RRVEIAHALC LSERQIKIWF QNRRMKWKKD HKLPNTKIRS GGAAGSAGGP PGRPNGGPRA L
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