About Homeobox protein Hox-B6
Homeobox protein Hox-B6 (HOXB6) is a protein
from Homo sapiens identified by UniProt accession
P17509, 224 residues long.
MolForge cross-references it against 0 known binders and
113 disease associations.
Target properties
| Protein name | Homeobox protein Hox-B6 |
|---|
| UniProt accession | P17509 |
|---|
| Gene | HOXB6 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 224 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (113)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.24
- hip bone mineral density · score 0.19
- hip bone size · score 0.17
- grip strength measurement · score 0.14
- body mass index · score 0.13
- Meckel syndrome · score 0.12
- mean arterial pressure · score 0.10
- low density lipoprotein cholesterol measurement · score 0.10
- autosomal recessive spondylocostal dysostosis · score 0.07
- FEV/FVC ratio · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P17509-F1 | alphafold | PREDICTED | 64.61 | — |
Amino-acid sequence (224 residues)
MSSYFVNSTF PVTLASGQES FLGQLPLYSS GYADPLRHYP APYGPGPGQD KGFATSSYYP PAGGGYGRAA PCDYGPAPAF YREKESACAL SGADEQPPFH PEPRKSDCAQ DKSVFGETEE QKCSTPVYPW MQRMNSCNSS SFGPSGRRGR QTYTRYQTLE LEKEFHYNRY LTRRRRIEIA HALCLTERQI KIWFQNRRMK WKKESKLLSA SQLSAEEEEE KQAE
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