Aldo-keto reductase family 1 member C4 (AKR1C4)

About Aldo-keto reductase family 1 member C4

Aldo-keto reductase family 1 member C4 (AKR1C4) is a protein from Homo sapiens identified by UniProt accession P17516, 323 residues long. MolForge cross-references it against 0 known binders and 110 disease associations.

Target properties

Protein name	Aldo-keto reductase family 1 member C4
UniProt accession	P17516
Gene	AKR1C4
Organism	Homo sapiens
Length	323 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (2)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (110)

Diseases linked to this target (Open Targets).

sex hormone-binding globulin measurement · score 0.44
triglyceride measurement · score 0.44
alkaline phosphatase measurement · score 0.41
testosterone measurement · score 0.40
hemoglobin measurement · score 0.40
bilirubin measurement · score 0.37
apolipoprotein A 1 measurement · score 0.37
serum gamma-glutamyl transferase measurement · score 0.36
total cholesterol measurement · score 0.36
lymphocyte count · score 0.36

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P17516-F1	alphafold	PREDICTED	96.90	—

Amino-acid sequence (323 residues)

MDPKYQRVEL NDGHFMPVLG FGTYAPPEVP RNRAVEVTKL AIEAGFRHID SAYLYNNEEQ VGLAIRSKIA DGSVKREDIF YTSKLWCTFF QPQMVQPALE SSLKKLQLDY VDLYLLHFPM ALKPGETPLP KDENGKVIFD TVDLSATWEV MEKCKDAGLA KSIGVSNFNC RQLEMILNKP GLKYKPVCNQ VECHPYLNQS KLLDFCKSKD IVLVAHSALG TQRHKLWVDP NSPVLLEDPV LCALAKKHKQ TPALIALRYQ LQRGVVVLAK SYNEQRIREN IQVFEFQLTS EDMKVLDGLN RNYRYVVMDF LMDHPDYPFS DEY

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards