Creatine kinase S-type, mitochondrial (CKMT2)

About Creatine kinase S-type, mitochondrial

Creatine kinase S-type, mitochondrial (CKMT2) is a protein from Homo sapiens identified by UniProt accession P17540, 419 residues long. MolForge cross-references it against 0 known binders and 112 disease associations.

Target properties

Protein name	Creatine kinase S-type, mitochondrial
UniProt accession	P17540
Gene	CKMT2
Organism	Homo sapiens
Length	419 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (112)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.18
Parkinson disease · score 0.18
multiple sclerosis · score 0.18
Alzheimer disease · score 0.18
lysosomal storage disease · score 0.18
genetic disorder · score 0.12
protein measurement · score 0.10
cancer · score 0.08
hypertrophic cardiomyopathy · score 0.07
familial atrial fibrillation · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P17540-F1	alphafold	PREDICTED	89.41	—

Amino-acid sequence (419 residues)

MASIFSKLLT GRNASLLFAT MGTSVLTTGY LLNRQKVCAE VREQPRLFPP SADYPDLRKH NNCMAECLTP AIYAKLRNKV TPNGYTLDQC IQTGVDNPGH PFIKTVGMVA GDEESYEVFA DLFDPVIKLR HNGYDPRVMK HTTDLDASKI TQGQFDEHYV LSSRVRTGRS IRGLSLPPAC TRAERREVEN VAITALEGLK GDLAGRYYKL SEMTEQDQQR LIDDHFLFDK PVSPLLTCAG MARDWPDARG IWHNYDKTFL IWINEEDHTR VISMEKGGNM KRVFERFCRG LKEVERLIQE RGWEFMWNER LGYILTCPSN LGTGLRAGVH VRIPKLSKDP RFSKILENLR LQKRGTGGVD TAAVADVYDI SNIDRIGRSE VELVQIVIDG VNYLVDCEKK LERGQDIKVP PPLPQFGKK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards