T-cell acute lymphocytic leukemia protein 1 (TAL1)

About T-cell acute lymphocytic leukemia protein 1

T-cell acute lymphocytic leukemia protein 1 (TAL1) is a protein from Homo sapiens identified by UniProt accession P17542, 331 residues long. MolForge cross-references it against 0 known binders and 461 disease associations.

Target properties

Protein name	T-cell acute lymphocytic leukemia protein 1
UniProt accession	P17542
Gene	TAL1
Organism	Homo sapiens
Length	331 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (461)

Diseases linked to this target (Open Targets).

mean corpuscular volume · score 0.43
mean corpuscular hemoglobin concentration · score 0.42
mean corpuscular hemoglobin · score 0.41
Red cell distribution width · score 0.39
body mass index · score 0.38
T-cell acute lymphoblastic leukemia · score 0.38
Cutaneous T-cell lymphoma · score 0.37
unspecified peripheral T-cell lymphoma · score 0.37
T-lymphoblastic lymphoma · score 0.37
mean platelet volume · score 0.37

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P17542-F1	alphafold	PREDICTED	60.38	—

Amino-acid sequence (331 residues)

MTERPPSEAA RSDPQLEGRD AAEASMAPPH LVLLNGVAKE TSRAAAAEPP VIELGARGGP GGGPAGGGGA ARDLKGRDAA TAEARHRVPT TELCRPPGPA PAPAPASVTA ELPGDGRMVQ LSPPALAAPA APGRALLYSL SQPLASLGSG FFGEPDAFPM FTTNNRVKRR PSPYEMEITD GPHTKVVRRI FTNSRERWRQ QNVNGAFAEL RKLIPTHPPD KKLSKNEILR LAMKYINFLA KLLNDQEEEG TQRAKTGKDP VVGAGGGGGG GGGGAPPDDL LQDVLSPNSS CGSSLDGAAS PDSYTEEPAP KHTARSLHPA MLPAADGAGP R

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards