Cyclic AMP-dependent transcription factor ATF-7 (ATF7)

About Cyclic AMP-dependent transcription factor ATF-7

Cyclic AMP-dependent transcription factor ATF-7 (ATF7) is a protein from Homo sapiens identified by UniProt accession P17544, 483 residues long. MolForge cross-references it against 0 known binders and 61 disease associations.

Target properties

Protein name	Cyclic AMP-dependent transcription factor ATF-7
UniProt accession	P17544
Gene	ATF7
Organism	Homo sapiens
Length	483 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (61)

Diseases linked to this target (Open Targets).

neutrophil count · score 0.35
neutrophil percentage of leukocytes · score 0.32
monocyte percentage of leukocytes · score 0.31
basophil count · score 0.30
body height · score 0.30
lymphocyte percentage of leukocytes · score 0.29
monocyte count · score 0.26
appendicular lean mass · score 0.26
myeloid white cell count · score 0.25
leukocyte count · score 0.23

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P17544-F1	alphafold	PREDICTED	60.08	—

Amino-acid sequence (483 residues)

MGDDRPFVCN APGCGQRFTN EDHLAVHKHK HEMTLKFGPA RTDSVIIADQ TPTPTRFLKN CEEVGLFNEL ASSFEHEFKK AADEDEKKAA AGPLDMSLPS TPDIKIKEEE PVEVDSSPPD SPASSPCSPP LKEKEVTPKP VLISTPTPTI VRPGSLPLHL GYDPLHPTLP SPTSVITQAP PSNRQMGSPT GSLPLVMHLA NGQTMPVLPG PPVQMPSVIS LARPVSMVPN IPGIPGPPVN SSGSISPSGH PIPSEAKMRL KATLTHQVSS INGGCGMVVG TASTMVTARP EQSQILIQHP DAPSPAQPQV SPAQPTPSTG GRRRRTVDED PDERRQRFLE RNRAAASRCR QKRKLWVSSL EKKAEELTSQ NIQLSNEVTL LRNEVAQLKQ LLLAHKDCPV TALQKKTQGY LESPKESSEP TGSPAPVIQH SSATAPSNGL SVRSAAEAVA TSVLTQMASQ RTELSMPIQS HVIMTPQSQS AGR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards