About cAMP-dependent protein kinase catalytic subunit alpha
cAMP-dependent protein kinase catalytic subunit alpha (PRKACA) is a protein
from Homo sapiens identified by UniProt accession
P17612, 351 residues long.
MolForge cross-references it against 0 known binders and
206 disease associations.
Target properties
| Protein name | cAMP-dependent protein kinase catalytic subunit alpha |
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| UniProt accession | P17612 |
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| Gene | PRKACA |
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| Organism | Homo sapiens |
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| Length | 351 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (8)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (206)
Diseases linked to this target (Open Targets).
- cardioacrofacial dysplasia 1 · score 0.65
- primary pigmented nodular adrenocortical disease · score 0.42
- Fibrolamellar Carcinoma · score 0.37
- bile duct adenocarcinoma · score 0.37
- Cortisol-Producing Adrenal Cortex Adenoma · score 0.37
- hepatocellular adenoma · score 0.37
- Hepatoblastoma · score 0.37
- Ellis Van Creveld syndrome · score 0.37
- lung adenocarcinoma · score 0.34
- ACTH-independent adrenal Cushing syndrome, somatic · score 0.33
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P17612-F1 | alphafold | PREDICTED | 95.53 | — |
Amino-acid sequence (351 residues)
MGNAAAAKKG SEQESVKEFL AKAKEDFLKK WESPAQNTAH LDQFERIKTL GTGSFGRVML VKHKETGNHY AMKILDKQKV VKLKQIEHTL NEKRILQAVN FPFLVKLEFS FKDNSNLYMV MEYVPGGEMF SHLRRIGRFS EPHARFYAAQ IVLTFEYLHS LDLIYRDLKP ENLLIDQQGY IQVTDFGFAK RVKGRTWTLC GTPEYLAPEI ILSKGYNKAV DWWALGVLIY EMAAGYPPFF ADQPIQIYEK IVSGKVRFPS HFSSDLKDLL RNLLQVDLTK RFGNLKNGVN DIKNHKWFAT TDWIAIYQRK VEAPFIPKFK GPGDTSNFDD YEEEEIRVSI NEKCGKEFSE F
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