About Calpain-2 catalytic subunit
Calpain-2 catalytic subunit (CAPN2) is a protein
from Homo sapiens identified by UniProt accession
P17655, 700 residues long.
MolForge cross-references it against 0 known binders and
212 disease associations.
Target properties
| Protein name | Calpain-2 catalytic subunit |
|---|
| UniProt accession | P17655 |
|---|
| Gene | CAPN2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 700 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (212)
Diseases linked to this target (Open Targets).
- Alzheimer disease · score 0.37
- eosinophil count · score 0.25
- breast adenocarcinoma · score 0.22
- atherosclerosis · score 0.10
- Myocardial Ischemia · score 0.09
- cortical surface area measurement · score 0.09
- angina pectoris · score 0.09
- coronary atherosclerosis · score 0.09
- serum gamma-glutamyl transferase measurement · score 0.09
- glucuronate measurement · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P17655-F1 | alphafold | PREDICTED | 89.32 | — |
Amino-acid sequence (700 residues)
MAGIAAKLAK DREAAEGLGS HDRAIKYLNQ DYEALRNECL EAGTLFQDPS FPAIPSALGF KELGPYSSKT RGIEWKRPTE ICADPQFIIG GATRTDICQG ALGDCWLLAA IASLTLNEEI LARVVPLNQS FQENYAGIFH FQFWQYGEWV EVVVDDRLPT KDGELLFVHS AEGSEFWSAL LEKAYAKING CYEALSGGAT TEGFEDFTGG IAEWYELKKP PPNLFKIIQK ALQKGSLLGC SIDITSAADS EAITFQKLVK GHAYSVTGAE EVESNGSLQK LIRIRNPWGE VEWTGRWNDN CPSWNTIDPE ERERLTRRHE DGEFWMSFSD FLRHYSRLEI CNLTPDTLTS DTYKKWKLTK MDGNWRRGST AGGCRNYPNT FWMNPQYLIK LEEEDEDEED GESGCTFLVG LIQKHRRRQR KMGEDMHTIG FGIYEVPEEL SGQTNIHLSK NFFLTNRARE RSDTFINLRE VLNRFKLPPG EYILVPSTFE PNKDGDFCIR VFSEKKADYQ AVDDEIEANL EEFDISEDDI DDGFRRLFAQ LAGEDAEISA FELQTILRRV LAKRQDIKSD GFSIETCKIM VDMLDSDGSG KLGLKEFYIL WTKIQKYQKI YREIDVDRSG TMNSYEMRKA LEEAGFKMPC QLHQVIVARF ADDQLIIDFD NFVRCLVRLE TLFKIFKQLD PENTGTIELD LISWLCFSVL
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