Desmin (DES)

About Desmin

Desmin (DES) is a protein from Homo sapiens identified by UniProt accession P17661, 470 residues long. MolForge cross-references it against 0 known binders and 1,097 disease associations.

Target properties

Protein name	Desmin
UniProt accession	P17661
Gene	DES
Organism	Homo sapiens
Length	470 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (1097)

Diseases linked to this target (Open Targets).

Desminopathy · score 0.85
myofibrillar myopathy 1 · score 0.83
dilated cardiomyopathy 1I · score 0.78
neurogenic scapuloperoneal syndrome, Kaeser type · score 0.71
Scapuloperoneal amyotrophy · score 0.70
Autosomal recessive limb-girdle muscular dystrophy due to desmin deficiency · score 0.67
dilated cardiomyopathy · score 0.65
myofibrillar myopathy · score 0.64
cardiomyopathy · score 0.58
arrhythmogenic right ventricular cardiomyopathy · score 0.50

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P17661-F1	alphafold	PREDICTED	76.55	—

Amino-acid sequence (470 residues)

MSQAYSSSQR VSSYRRTFGG APGFPLGSPL SSPVFPRAGF GSKGSSSSVT SRVYQVSRTS GGAGGLGSLR ASRLGTTRTP SSYGAGELLD FSLADAVNQE FLTTRTNEKV ELQELNDRFA NYIEKVRFLE QQNAALAAEV NRLKGREPTR VAELYEEELR ELRRQVEVLT NQRARVDVER DNLLDDLQRL KAKLQEEIQL KEEAENNLAA FRADVDAATL ARIDLERRIE SLNEEIAFLK KVHEEEIREL QAQLQEQQVQ VEMDMSKPDL TAALRDIRAQ YETIAAKNIS EAEEWYKSKV SDLTQAANKN NDALRQAKQE MMEYRHQIQS YTCEIDALKG TNDSLMRQMR ELEDRFASEA SGYQDNIARL EEEIRHLKDE MARHLREYQD LLNVKMALDV EIATYRKLLE GEESRINLPI QTYSALNFRE TSPEQRGSEV HTKKTVMIKT IETRDGEVVS EATQQQHEVL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards