CCAAT/enhancer-binding protein beta (CEBPB)

About CCAAT/enhancer-binding protein beta

CCAAT/enhancer-binding protein beta (CEBPB) is a protein from Homo sapiens identified by UniProt accession P17676, 345 residues long. MolForge cross-references it against 0 known binders and 663 disease associations.

Target properties

Protein name	CCAAT/enhancer-binding protein beta
UniProt accession	P17676
Gene	CEBPB
Organism	Homo sapiens
Length	345 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (663)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.53
monocyte count · score 0.47
monocyte percentage of leukocytes · score 0.44
inflammatory bowel disease · score 0.38
diabetes mellitus · score 0.37
neuroinflammatory disorder · score 0.37
testosterone measurement · score 0.37
type 2 diabetes mellitus · score 0.37
granulocyte percentage of myeloid white cells · score 0.33
breast carcinoma · score 0.31

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P17676-F1	alphafold	PREDICTED	59.69	—

Amino-acid sequence (345 residues)

MQRLVAWDPA CLPLPPPPPA FKSMEVANFY YEADCLAAAY GGKAAPAAPP AARPGPRPPA GELGSIGDHE RAIDFSPYLE PLGAPQAPAP ATATDTFEAA PPAPAPAPAS SGQHHDFLSD LFSDDYGGKN CKKPAEYGYV SLGRLGAAKG ALHPGCFAPL HPPPPPPPPP AELKAEPGFE PADCKRKEEA GAPGGGAGMA AGFPYALRAY LGYQAVPSGS SGSLSTSSSS SPPGTPSPAD AKAPPTACYA GAAPAPSQVK SKAKKTVDKH SDEYKIRRER NNIAVRKSRD KAKMRNLETQ HKVLELTAEN ERLQKKVEQL SRELSTLRNL FKQLPEPLLA SSGHC

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards