About Neuromodulin
Neuromodulin (GAP43) is a protein
from Homo sapiens identified by UniProt accession
P17677, 238 residues long.
MolForge cross-references it against 0 known binders and
277 disease associations.
Target properties
| Protein name | Neuromodulin |
|---|
| UniProt accession | P17677 |
|---|
| Gene | GAP43 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 238 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (277)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.43
- mathematical ability · score 0.34
- diet measurement · score 0.34
- DNA methylation · score 0.29
- smoking status measurement · score 0.26
- neurofibrillary tangles measurement · score 0.26
- pulse pressure measurement · score 0.25
- brain measurement · score 0.25
- neuroimaging measurement · score 0.22
- systolic blood pressure · score 0.22
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P17677-F1 | alphafold | PREDICTED | 55.02 | — |
Amino-acid sequence (238 residues)
MLCCMRRTKQ VEKNDDDQKI EQDGIKPEDK AHKAATKIQA SFRGHITRKK LKGEKKDDVQ AAEAEANKKD EAPVADGVEK KGEGTTTAEA APATGSKPDE PGKAGETPSE EKKGEGDAAT EQAAPQAPAS SEEKAGSAET ESATKASTDN SPSSKAEDAP AKEEPKQADV PAAVTAAAAT TPAAEDAAAK ATAQPPTETG ESSQAEENIE AVDETKPKES ARQDEGKEEE PEADQEHA
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