About HLA class I histocompatibility antigen, alpha chain G
HLA class I histocompatibility antigen, alpha chain G (HLA-G) is a protein
from Homo sapiens identified by UniProt accession
P17693, 338 residues long.
MolForge cross-references it against 0 known binders and
874 disease associations.
Target properties
| Protein name | HLA class I histocompatibility antigen, alpha chain G |
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| UniProt accession | P17693 |
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| Gene | HLA-G |
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| Organism | Homo sapiens |
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| Length | 338 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (874)
Diseases linked to this target (Open Targets).
- COVID-19 · score 0.49
- neutrophil-to-lymphocyte ratio · score 0.26
- smoking status measurement · score 0.26
- schizophrenia · score 0.24
- pemphigus foliaceus · score 0.23
- bipolar disorder · score 0.22
- response to lithium ion · score 0.21
- susceptibility to mumps measurement · score 0.19
- triglyceride measurement · score 0.19
- serum non-albumin protein measurement · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P17693-F1 | alphafold | PREDICTED | 90.47 | — |
Amino-acid sequence (338 residues)
MVVMAPRTLF LLLSGALTLT ETWAGSHSMR YFSAAVSRPG RGEPRFIAMG YVDDTQFVRF DSDSACPRME PRAPWVEQEG PEYWEEETRN TKAHAQTDRM NLQTLRGYYN QSEASSHTLQ WMIGCDLGSD GRLLRGYEQY AYDGKDYLAL NEDLRSWTAA DTAAQISKRK CEAANVAEQR RAYLEGTCVE WLHRYLENGK EMLQRADPPK THVTHHPVFD YEATLRCWAL GFYPAEIILT WQRDGEDQTQ DVELVETRPA GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL PEPLMLRWKQ SSLPTIPIMG IVAGLVVLAA VVTGAAVAAV LWRKKSSD
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