About Tyrosine-protein phosphatase non-receptor type 2
Tyrosine-protein phosphatase non-receptor type 2 (PTPN2) is a protein
from Homo sapiens identified by UniProt accession
P17706, 415 residues long.
MolForge cross-references it against 0 known binders and
428 disease associations.
Target properties
| Protein name | Tyrosine-protein phosphatase non-receptor type 2 |
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| UniProt accession | P17706 |
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| Gene | PTPN2 |
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| Organism | Homo sapiens |
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| Length | 415 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (428)
Diseases linked to this target (Open Targets).
- rheumatoid arthritis · score 0.52
- C-reactive protein measurement · score 0.49
- eosinophil count · score 0.49
- hemoglobin measurement · score 0.47
- erythrocyte count · score 0.46
- Crohn's disease · score 0.45
- type 1 diabetes mellitus · score 0.45
- hematocrit · score 0.45
- mean corpuscular volume · score 0.43
- ulcerative colitis · score 0.42
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P17706-F1 | alphafold | PREDICTED | 85.89 | — |
Amino-acid sequence (415 residues)
MPTTIEREFE ELDTQRRWQP LYLEIRNESH DYPHRVAKFP ENRNRNRYRD VSPYDHSRVK LQNAENDYIN ASLVDIEEAQ RSYILTQGPL PNTCCHFWLM VWQQKTKAVV MLNRIVEKES VKCAQYWPTD DQEMLFKETG FSVKLLSEDV KSYYTVHLLQ LENINSGETR TISHFHYTTW PDFGVPESPA SFLNFLFKVR ESGSLNPDHG PAVIHCSAGI GRSGTFSLVD TCLVLMEKGD DINIKQVLLN MRKYRMGLIQ TPDQLRFSYM AIIEGAKCIK GDSSIQKRWK ELSKEDLSPA FDHSPNKIMT EKYNGNRIGL EEEKLTGDRC TGLSSKMQDT MEENSESALR KRIREDRKAT TAQKVQQMKQ RLNENERKRK RWLYWQPILT KMGFMSVILV GAFVGWTLFF QQNAL
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