Tyrosine aminotransferase (TAT)

About Tyrosine aminotransferase

Tyrosine aminotransferase (TAT) is a protein from Homo sapiens identified by UniProt accession P17735, 454 residues long. MolForge cross-references it against 0 known binders and 91 disease associations.

Target properties

Protein name	Tyrosine aminotransferase
UniProt accession	P17735
Gene	TAT
Organism	Homo sapiens
Length	454 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (91)

Diseases linked to this target (Open Targets).

Tyrosinemia type 2 · score 0.80
tyrosinemia type II · score 0.77
Intellectual disability · score 0.46
Palmoplantar hyperkeratosis · score 0.37
chronotype measurement · score 0.21
thyroid gland adenocarcinoma · score 0.18
genetic disorder · score 0.18
Hypertyrosinemia · score 0.17
tyrosine measurement · score 0.17
sex hormone-binding globulin measurement · score 0.16

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P17735-F1	alphafold	PREDICTED	91.74	—

Amino-acid sequence (454 residues)

MDPYMIQMSS KGNLPSILDV HVNVGGRSSV PGKMKGRKAR WSVRPSDMAK KTFNPIRAIV DNMKVKPNPN KTMISLSIGD PTVFGNLPTD PEVTQAMKDA LDSGKYNGYA PSIGFLSSRE EIASYYHCPE APLEAKDVIL TSGCSQAIDL CLAVLANPGQ NILVPRPGFS LYKTLAESMG IEVKLYNLLP EKSWEIDLKQ LEYLIDEKTA CLIVNNPSNP CGSVFSKRHL QKILAVAARQ CVPILADEIY GDMVFSDCKY EPLATLSTDV PILSCGGLAK RWLVPGWRLG WILIHDRRDI FGNEIRDGLV KLSQRILGPC TIVQGALKSI LCRTPGEFYH NTLSFLKSNA DLCYGALAAI PGLRPVRPSG AMYLMVGIEM EHFPEFENDV EFTERLVAEQ SVHCLPATCF EYPNFIRVVI TVPEVMMLEA CSRIQEFCEQ HYHCAEGSQE ECDK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards