Tryptophan 5-hydroxylase 1 (TPH1)

About Tryptophan 5-hydroxylase 1

Tryptophan 5-hydroxylase 1 (TPH1) is a protein from Homo sapiens identified by UniProt accession P17752, 444 residues long. MolForge cross-references it against 0 known binders and 399 disease associations.

Target properties

Protein name	Tryptophan 5-hydroxylase 1
UniProt accession	P17752
Gene	TPH1
Organism	Homo sapiens
Length	444 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (1)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (399)

Diseases linked to this target (Open Targets).

neuroendocrine neoplasm · score 0.48
carcinoid tumor · score 0.46
Diarrhea · score 0.46
carcinoid syndrome · score 0.37
small intestine neuroendocrine tumor, well differentiated, low or intermediate grade · score 0.26
large cell neuroendocrine carcinoma · score 0.26
carcinoid heart disease · score 0.26
lung adenocarcinoma · score 0.22
leukocyte count · score 0.17
body height · score 0.16

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P17752-F1	alphafold	PREDICTED	87.96	—

Amino-acid sequence (444 residues)

MIEDNKENKD HSLERGRASL IFSLKNEVGG LIKALKIFQE KHVNLLHIES RKSKRRNSEF EIFVDCDINR EQLNDIFHLL KSHTNVLSVN LPDNFTLKED GMETVPWFPK KISDLDHCAN RVLMYGSELD ADHPGFKDNV YRKRRKYFAD LAMNYKHGDP IPKVEFTEEE IKTWGTVFQE LNKLYPTHAC REYLKNLPLL SKYCGYREDN IPQLEDVSNF LKERTGFSIR PVAGYLSPRD FLSGLAFRVF HCTQYVRHSS DPFYTPEPDT CHELLGHVPL LAEPSFAQFS QEIGLASLGA SEEAVQKLAT CYFFTVEFGL CKQDGQLRVF GAGLLSSISE LKHALSGHAK VKPFDPKITC KQECLITTFQ DVYFVSESFE DAKEKMREFT KTIKRPFGVK YNPYTRSIQI LKDTKSITSA MNELQHDLDV VSDALAKVSR KPSI

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards