About Neuronal acetylcholine receptor subunit beta-2
Neuronal acetylcholine receptor subunit beta-2 (CHRNB2) is a protein
from Homo sapiens identified by UniProt accession
P17787, 502 residues long.
MolForge cross-references it against 0 known binders and
240 disease associations.
Target properties
| Protein name | Neuronal acetylcholine receptor subunit beta-2 |
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| UniProt accession | P17787 |
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| Gene | CHRNB2 |
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| Organism | Homo sapiens |
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| Length | 502 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (240)
Diseases linked to this target (Open Targets).
- autosomal dominant nocturnal frontal lobe epilepsy · score 0.64
- nicotine dependence · score 0.61
- smoking cessation · score 0.60
- schizophrenia · score 0.56
- dry eye syndrome · score 0.56
- alcohol dependence · score 0.55
- pain · score 0.54
- schizoaffective disorder · score 0.51
- major depressive disorder · score 0.50
- Parkinson disease · score 0.48
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P17787-F1 | alphafold | PREDICTED | 80.27 | — |
Amino-acid sequence (502 residues)
MARRCGPVAL LLGFGLLRLC SGVWGTDTEE RLVEHLLDPS RYNKLIRPAT NGSELVTVQL MVSLAQLISV HEREQIMTTN VWLTQEWEDY RLTWKPEEFD NMKKVRLPSK HIWLPDVVLY NNADGMYEVS FYSNAVVSYD GSIFWLPPAI YKSACKIEVK HFPFDQQNCT MKFRSWTYDR TEIDLVLKSE VASLDDFTPS GEWDIVALPG RRNENPDDST YVDITYDFII RRKPLFYTIN LIIPCVLITS LAILVFYLPS DCGEKMTLCI SVLLALTVFL LLISKIVPPT SLDVPLVGKY LMFTMVLVTF SIVTSVCVLN VHHRSPTTHT MAPWVKVVFL EKLPALLFMQ QPRHHCARQR LRLRRRQRER EGAGALFFRE APGADSCTCF VNRASVQGLA GAFGAEPAPV AGPGRSGEPC GCGLREAVDG VRFIADHMRS EDDDQSVSED WKYVAMVIDR LFLWIFVFVC VFGTIGMFLQ PLFQNYTTTT FLHSDHSAPS SK
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